Frank Bigelow (Edmond O'Brien) is a small town accountant. After going out for an evening while on vacation in San Francisco Frank wakes up with more than just a hangover; doctors tell him he's been given a "luminous toxin" with no antidote and has, at most, a week to live.
Not knowing who has poisoned him, Frank goes on a frantic search for his murderer. Directed by Rudolph Maté and released by United Artists, DOA is a classic example of film noir.
Some trace the film's plot to Der Mann der Seinen Mörder Sucht, a 1931 German film by Robert Siodmak. The film was remade in 1969 (as the Australian Color Me Dead) and again in 1988 with Dennis Quaid as the protagonist.
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